British Air Force Typhoon fighter aircraft have operated alongside French aircraft in a coordinated attack against an subterranean weapons facility in Syrian territory employed by the IS group, as stated by the UK's MoD.
The facility, pinpointed through intelligence, was thought to be storing arms and explosives, the statement said, and was positioned in hills just above Palmyra in Syria's central region.
"Our aircraft employed laser-guided Paveway IV weapons to strike a series of approach shafts leading to the depot... initial indications suggest the strike was effective," officials stated.
There was no sign of any harm to civilians in the attack late on Saturday and all the aircraft returned safely, the MoD added.
The British jets were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as Daesh - established extremist governance over large swathes of Syria and Iraq prior to its 2019 collapse.
"This operation underscores our UK leadership, and commitment to work closely with allied nations, to eliminate any revival of Daesh and their harmful and extremist ideologies in the Middle East," the British Defence Secretary John Healey said.
UK warplanes have performed patrols over Syria to "forestall any attempted comeback" of IS subsequent to its military defeat at the Baghuz confrontation in 2019, the ministry said.
"I want to thank all the members of our armed forces participating in this mission for their professionalism and their bravery," the Defence Secretary commented. "Including them were numerous British troops deployed over the festive period. This action, to remove militants who endanger our security, demonstrates how British military are ready to step up, throughout the year, ensuring Britain's security within its borders and powerful internationally."
Last December, the American forces executed what it described as a "large-scale strike" on IS targets in the country, after an attack claimed the lives of two US troops and a civilian linguist in the Palmyra area.
The UN says Daesh still has between 5,000 and 7,000 militants in Iraq and Syria.